Glycosylation — the attachment of sugar chains to proteins and lipids — is not a static modification. My research centres on understanding how cells dynamically remodel their surface glycan landscape to control fundamental processes including endocytosis, cell differentiation, and immune evasion. Rather than treating glycans as fixed structural features, I investigate how their composition is actively regulated by signalling and metabolic programmes to drive rapid, reversible changes in cell state.
Ewan MacDonald is a postdoctoral researcher at the Institut de Recherche en Cancérologie de Montpellier (IRCM, INSERM U1194), Montpellier, France. He completed his PhD at the University of Liverpool under Prof. Michael Clague, followed by postdoctoral positions at the University of Liverpool and Institut Curie, Paris. His work has been published in Nature Cell Biology, Journal of Cell Biology, and Current Opinion in Cell Biology, among others.